Deep Brain Stimulation Study Offers Hope for Severe Depression Patients

Results of Brodmann Area 25 Deep Brain Stimulation Pilot Study Offer Hope for Patients with Severe Depression

Study findings presented today at American Psychiatric Association Annual Meeting

ST. PAUL, Minn.-- May 05, 2008 --St. Jude Medical, Inc. (NYSE:STJ) today announced pilot study results from the first multi-center study investigating deep brain stimulation (DBS) of Brodmann Area 25 for major depressive disorder.

Results of the study, which were presented today at the American Psychiatric Association (APA) meeting in Washington, D.C., found that 6 months after the procedure, 56 percent of the patients experienced at least a 40 percent decrease in depressive symptoms. Patient's symptoms were measured using a standardized test called the Hamilton Rating Scale for Depression.

Results were presented by Sidney Kennedy, M.D., psychiatrist-in-chief with the University Health Network in Toronto. "Severe depression destroys a person's ability to be productive and have a normal quality of life," said Dr. Kennedy. "The results from this study are very promising, and we are hopeful that our research will lead to a therapy that can help these patients."

Prior to beginning the study, all patients were classified as having severe depression after multiple treatments - such as medications, psychotherapy and electroconvulsive therapy - had failed to provide sustained relief from depression. Each study patient had tried a minimum of 12 depression medications over his or her lifetime.

DBS was targeted at an area of the brain known as Brodmann Area 25, which appears to become overactive when people are profoundly sad and depressed. Conducted at three leading Canadian academic medical centers, the study expands and supports the groundbreaking research of Helen Mayberg, M.D., and Andres Lozano, M.D., which was published in Neuron in March 2005.

On average, the 20 study participants had suffered from depression for more than 20 years; they were disabled and unable to work at the time of enrollment. The study also found that:

    * At their most recent psychiatric evaluation, 78 percent of the patients experienced at least a 40 percent decrease in depressive symptoms.
    * Three of the study patients are considered to be in remission.
    * Eight patients have re-engaged in life activities such as work, school, relationships and travel.

In the study, DBS was delivered through the St. Jude Medical Libra® Deep Brain Stimulation System, which delivers mild electrical current from a device implanted near the collarbone; the device is connected to small electrical leads placed at specific targets in the brain.

"These results are important as they help establish the body of evidence that will continue to move depression research forward," said Chris Chavez, president of the St. Jude Medical ANS Division. "We are committed to leading the development of products that can make life better for patients suffering from this debilitating condition."

Based on the results of this research, St. Jude Medical announced the BROADENT (BROdmann Area 25 DEep brain Neuromodulation) study in February 2008, to further investigate the use of DBS for major depressive disorder. A controlled, multi-center, blinded clinical study, BROADEN is being conducted in the U.S. under an Investigational Device Exemption (IDE) from the U.S. Food and Drug Administration (FDA).

St. Jude Medical owns the intellectual property rights and has various patents issued and pending for the use of neurostimulation at Brodmann Area 25. For more information about this clinical trial, call toll-free 866-787-4332 or visit www.BROADENstudy.com.

According to the National Advisory Mental Health Council, of the 21 million adult Americans who suffer from depression, approximately 4 million live with severe depression that does not respond to medications, psychotherapy and, in certain cases, electroconvulsive therapy.

About St. Jude Medical

St. Jude Medical is dedicated to making life better for cardiac, neurological and chronic pain patients worldwide through excellence in medical device technology and services. The Company has five major focus areas that include: cardiac rhythm management, atrial fibrillation, cardiac surgery, cardiology and neuromodulation. Headquartered in St. Paul, Minn., St. Jude Medical employs more than 12,000 people worldwide. For more information, please visit www.sjm.com.

About the ANS Division of St. Jude Medical

The ANS Division (Advanced Neuromodulation Systems) became a part of St. Jude Medical in 2005. The ANS Division is an innovative technology leader dedicated to the design, development, manufacturing and marketing of implantable neuromodulation systems to improve the quality of life for people suffering from disabling chronic pain and other nervous system disorders (www.ans-medical.com).

Forward-Looking Statements

This news release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that involve risks and uncertainties. Such forward-looking statements include the expectations, plans and prospects for the Company, including potential clinical successes, anticipated regulatory approvals and future product launches, and projected revenues, margins, earnings, and market shares. The statements made by the Company are based upon management's current expectations and are subject to certain risks and uncertainties that could cause actual results to differ materially from those described in the forward-looking statements. These risks and uncertainties include market conditions and other factors beyond the Company's control and the risk factors and other cautionary statements described in the Company's filings with the SEC, including those described in the Company's Annual Report on Form 10-K filed on February 27, 2008 (see Item 1A on pages 13-20, and page 20 of Exhibit 13 to the Company's Form 10-K). The Company does not intend to update these statements and undertakes no duty to any person to provide any such update under any circumstance.

Contacts

St. Jude Medical, Inc.
Investor Relations:
Angela Craig, 651-481-7789
or
Media Relations:
Kathleen Janasz, 651-415-7042
Mobile: 612-743-8995
or
Denise Landry, 972-309-8085

Sexy Lingerie Web Store

Simpley Sexy Lingerie Opens Web Store

www.SimpleySexyLingerie.com has opened their new web store, offering tastefully tantalizing items in a variety of styles and sizes.

Woodland, NC  -  March 30, 2008 -- Store owner Pamela Collier has opened her new boutique at www.SimpleySexyLingerie.com, displaying a variety of lingerie items in attractive but tasteful styles. "Just the idea of being able to do something and kind of focus it on myself led me to opening the store," says Pamela, a longtime Internet shopper, mother of 2, and grandmother to a 2-year-old grandson.

"Being able to wear lingerie makes you feel good about yourself," says Pamela, who researched her products carefully before opening her store. As a devout Christian, it was important to her to strike a balance between alluring products and wholesome items. "I want women to realize that they can still be a mother or wife and feel sexy. It's very important to me that women feel beautiful, no matter what their size, if they're Christian, a mother or even a grandmother. Women deserve to be able to wear lingerie and feel sexy without being embarrassed. I want people to be able to shop in the convenience of their own homes and not have to go out and feel like people are staring and judging them."

In trying to maintain a clean and tasteful image, Pamela has selected her products personally, looking them over and making certain they meet her standards. "There are many items that I didn't put on my web site because I didn't feel that they were appropriate," she says, maintaining a clean but sexy image for her site.

Pamela has also begun a blog at www.SimpleySexyLingerie.net, allowing her to interact with her customers and assist them directly. "I'll be talking about my products, including different seasonal items and lines," says Pamela, who plans on providing additional information on her merchandise through that venue. She also intends to discuss future plans with her customers, getting their feedback and assistance in the growth of her business. "I've got high hopes," she explains. "I'd like to see the web site grow and eventually start a couple other sites."

Press Contact: Pamela Collier
Company Name: Collier Enterprise, LLC
Phone: 252-209-4518
Website: www.simpleysexylingerie.com